The Idebenone/Ubiquinone Report

Ubiquinone, otherwise known as idebenone, is a powerful antioxidant with a lower molecular weight than its closest chemical cousin, coenzyme Q10. Previously, ubiquinone was shown to be a very effective antioxidant in its ability to protect against cell damage from oxidative stress in a variety of biochemical, cell biological, and in vivo methods, including its ability to suppress sunburn cell formation in living skin.

I had an easy time researching ubiquinone: there is a good amount of credible research to back up this little wonder molecule and it has been studied in many research models.

According to a 2008 report in the Journal of the American Academy of Dermatology, ubiquenone has been reported to have excellent anti-inflammatory and anti-oxidant properties when applied topically.

Research conducted by the Anti-Aging Institute in 2005 investigated the efficacy of treating photodamaged skin with idebenone gel (the form of ubiquinone that Lifecell uses). 41 women with moderate photodamaged skin were randomized and instructed to apply blind labeled (which means they had no idea what they were applying) idebenone to their face for six weeks. They were then assessed by blind experts (which means the experts had no idea what the women applied to their faces either).

After six weeks' use of the 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. For the 0.5% idebenone formulation, a 23% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 27% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin. Immunofluorescence staining of the women’s skin cells also revealed an increase in collagen I for both concentrations, which is an important component of skin cell structure.

Another 2005 study by the Anti-Aging Institute, reported in the Journal of Cosmetic Dermatology created a standardized method to characterize and compare anti-oxidant capabilities of the most potent ones out there, including idebenone, vitamin E, vitamin C, alpha lipoic acid, and ubiquinone. They used in vitro (test tube and Petri dish) and in vivo methods. After testing all the anti-oxidants, idebenone came out with the highest overall oxidative (aging) stress protection.

Ubiquinone is a very worthwhile antioxidant to use on your face. Both LifeCell and Revitol utilize this substance to protect and improve the appearance of the skin on your face and neck.